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116 Defense Hwy 1,335 - 10,029 SF of Office Space Available in Annapolis, MD 21401

Highlights

  • On-Site Gym
  • Ample Parking
  • Elevator
  • Quick Access to Major Highway Systems

All Available Spaces(6)

Display Rental Rate as

  • Space
  • Size
  • Term
  • Rental Rate
  • Space Use
  • Build-Out
  • Available
  • 1st Floor, Ste 105
  • 1,335 SF
  • Negotiable
  • $35.00 /SF/YR $2.92 /SF/MO $376.74 /m²/YR $31.39 /m²/MO $3,894 /MO $46,725 /YR
  • Office
  • Full Build-Out
  • Now
  • Rate includes utilities, building services and property expenses
  • Fits 4 - 11 People
  • Fully Built-Out as Standard Office
  • 2nd Floor, Ste 201
  • 2,206 SF
  • Negotiable
  • $35.00 /SF/YR $2.92 /SF/MO $376.74 /m²/YR $31.39 /m²/MO $6,434 /MO $77,210 /YR
  • Office
  • Full Build-Out
  • Now
  • Rate includes utilities, building services and property expenses
  • Fits 6 - 18 People
  • Fully Built-Out as Standard Office
  • 2nd Floor, Ste 207
  • 1,403 SF
  • Negotiable
  • $35.00 /SF/YR $2.92 /SF/MO $376.74 /m²/YR $31.39 /m²/MO $4,092 /MO $49,105 /YR
  • Office
  • Full Build-Out
  • Now
  • Rate includes utilities, building services and property expenses
  • Fits 4 - 12 People
  • Fully Built-Out as Standard Office
  • 3rd Floor, Ste 301
  • 1,403 SF
  • Negotiable
  • $35.00 /SF/YR $2.92 /SF/MO $376.74 /m²/YR $31.39 /m²/MO $4,092 /MO $49,105 /YR
  • Office
  • Full Build-Out
  • Now
  • Rate includes utilities, building services and property expenses
  • Fits 4 - 12 People
  • Fully Built-Out as Standard Office
  • 4th Floor, Ste 401
  • 1,749 SF
  • Negotiable
  • $35.00 /SF/YR $2.92 /SF/MO $376.74 /m²/YR $31.39 /m²/MO $5,101 /MO $61,215 /YR
  • Office
  • Full Build-Out
  • Now
  • Rate includes utilities, building services and property expenses
  • Fits 5 - 14 People
  • Fully Built-Out as Standard Office
  • 5th Floor, Ste 503
  • 1,933 SF
  • Negotiable
  • $35.00 /SF/YR $2.92 /SF/MO $376.74 /m²/YR $31.39 /m²/MO $5,638 /MO $67,655 /YR
  • Office
  • Full Build-Out
  • Now
  • Rate includes utilities, building services and property expenses
  • Fits 5 - 16 People
  • Fully Built-Out as Standard Office
Space Size Term Rental Rate Space Use Build-Out Available
1st Floor, Ste 105 1,335 SF Negotiable $35.00 /SF/YR $2.92 /SF/MO $376.74 /m²/YR $31.39 /m²/MO $3,894 /MO $46,725 /YR Office Full Build-Out Now
2nd Floor, Ste 201 2,206 SF Negotiable $35.00 /SF/YR $2.92 /SF/MO $376.74 /m²/YR $31.39 /m²/MO $6,434 /MO $77,210 /YR Office Full Build-Out Now
2nd Floor, Ste 207 1,403 SF Negotiable $35.00 /SF/YR $2.92 /SF/MO $376.74 /m²/YR $31.39 /m²/MO $4,092 /MO $49,105 /YR Office Full Build-Out Now
3rd Floor, Ste 301 1,403 SF Negotiable $35.00 /SF/YR $2.92 /SF/MO $376.74 /m²/YR $31.39 /m²/MO $4,092 /MO $49,105 /YR Office Full Build-Out Now
4th Floor, Ste 401 1,749 SF Negotiable $35.00 /SF/YR $2.92 /SF/MO $376.74 /m²/YR $31.39 /m²/MO $5,101 /MO $61,215 /YR Office Full Build-Out Now
5th Floor, Ste 503 1,933 SF Negotiable $35.00 /SF/YR $2.92 /SF/MO $376.74 /m²/YR $31.39 /m²/MO $5,638 /MO $67,655 /YR Office Full Build-Out Now

1st Floor, Ste 105

Size
1,335 SF
Term
Negotiable
Rental Rate
$35.00 /SF/YR $2.92 /SF/MO $376.74 /m²/YR $31.39 /m²/MO $3,894 /MO $46,725 /YR
Space Use
Office
Build-Out
Full Build-Out
Available
Now

2nd Floor, Ste 201

Size
2,206 SF
Term
Negotiable
Rental Rate
$35.00 /SF/YR $2.92 /SF/MO $376.74 /m²/YR $31.39 /m²/MO $6,434 /MO $77,210 /YR
Space Use
Office
Build-Out
Full Build-Out
Available
Now

2nd Floor, Ste 207

Size
1,403 SF
Term
Negotiable
Rental Rate
$35.00 /SF/YR $2.92 /SF/MO $376.74 /m²/YR $31.39 /m²/MO $4,092 /MO $49,105 /YR
Space Use
Office
Build-Out
Full Build-Out
Available
Now

3rd Floor, Ste 301

Size
1,403 SF
Term
Negotiable
Rental Rate
$35.00 /SF/YR $2.92 /SF/MO $376.74 /m²/YR $31.39 /m²/MO $4,092 /MO $49,105 /YR
Space Use
Office
Build-Out
Full Build-Out
Available
Now

4th Floor, Ste 401

Size
1,749 SF
Term
Negotiable
Rental Rate
$35.00 /SF/YR $2.92 /SF/MO $376.74 /m²/YR $31.39 /m²/MO $5,101 /MO $61,215 /YR
Space Use
Office
Build-Out
Full Build-Out
Available
Now

5th Floor, Ste 503

Size
1,933 SF
Term
Negotiable
Rental Rate
$35.00 /SF/YR $2.92 /SF/MO $376.74 /m²/YR $31.39 /m²/MO $5,638 /MO $67,655 /YR
Space Use
Office
Build-Out
Full Build-Out
Available
Now

1st Floor, Ste 105

Size 1,335 SF
Term Negotiable
Rental Rate $35.00 /SF/YR
Space Use Office
Build-Out Full Build-Out
Available Now

  • Rate includes utilities, building services and property expenses
  • Fully Built-Out as Standard Office
  • Fits 4 - 11 People

2nd Floor, Ste 201

Size 2,206 SF
Term Negotiable
Rental Rate $35.00 /SF/YR
Space Use Office
Build-Out Full Build-Out
Available Now

  • Rate includes utilities, building services and property expenses
  • Fully Built-Out as Standard Office
  • Fits 6 - 18 People

2nd Floor, Ste 207

Size 1,403 SF
Term Negotiable
Rental Rate $35.00 /SF/YR
Space Use Office
Build-Out Full Build-Out
Available Now

  • Rate includes utilities, building services and property expenses
  • Fully Built-Out as Standard Office
  • Fits 4 - 12 People

3rd Floor, Ste 301

Size 1,403 SF
Term Negotiable
Rental Rate $35.00 /SF/YR
Space Use Office
Build-Out Full Build-Out
Available Now

  • Rate includes utilities, building services and property expenses
  • Fully Built-Out as Standard Office
  • Fits 4 - 12 People

4th Floor, Ste 401

Size 1,749 SF
Term Negotiable
Rental Rate $35.00 /SF/YR
Space Use Office
Build-Out Full Build-Out
Available Now

  • Rate includes utilities, building services and property expenses
  • Fully Built-Out as Standard Office
  • Fits 5 - 14 People

5th Floor, Ste 503

Size 1,933 SF
Term Negotiable
Rental Rate $35.00 /SF/YR
Space Use Office
Build-Out Full Build-Out
Available Now

  • Rate includes utilities, building services and property expenses
  • Fully Built-Out as Standard Office
  • Fits 5 - 16 People

Property Overview

116 Defense Highway is a highly sought-after Class A medical office building strategically located within Annapolis’ established medical and professional corridor. The approximately 81,931-square-foot property is home to a strong concentration of respected healthcare providers, including internal medicine, orthopedics, physical therapy, pulmonary care, regenerative medicine, and advanced diagnostic imaging services. The building offers an on-site gym with an ideal setting for medical and healthcare-related practices seeking a professional environment with convenient patient access and valuable referral opportunities from complementary providers within the property. Its central Annapolis location provides excellent connectivity to Route 50, Interstate 97, downtown Annapolis, Luminous Health Medical Center, and the surrounding communities of Anne Arundel County. With its established medical identity, prominent Defense Highway location, and proximity to major transportation routes and regional amenities, 116 Defense Highway represents a premier opportunity for practices looking to establish or expand their presence in the Annapolis market.

  • Fitness Center
  • Property Manager on Site
  • Signage
  • Central Heating
  • Air Conditioning

Property Facts

Building Type
Office
Year Built
1988
Building Height
5 Stories
Building Size
81,931 SF
Building Class
A
Typical Floor Size
16,386 SF
Unfinished Ceiling Height
10’
Parking
376 Surface Parking Spaces
Covered Parking

Select Tenants

  • Floor
  • Tenant Name
  • Industry
  • 5th
  • Annapolis Asthma, Pulmonary & Sleep Specialists
  • Health Care and Social Assistance
  • 4th
  • Annapolis Internal Medicine
  • Health Care and Social Assistance
  • 3rd
  • Barton & Loguidice
  • Professional, Scientific, and Technical Services
  • 3rd
  • Hartman Realty, LLC.
  • Finance and Insurance
  • 1st
  • Heart Health Foundation
  • Health Care and Social Assistance
  • 3rd
  • LabCorp
  • Health Care and Social Assistance
  • 1st
  • NovaCare Rehabilitation
  • Health Care and Social Assistance
  • 2nd
  • Sean Mulvaney MD
  • Health Care and Social Assistance
  • 5th
  • Vision Specialists of Annapolis
  • Health Care and Social Assistance
  • 2nd
  • Washington Nephrology Associates
  • Health Care and Social Assistance
1 1
116 Defense Hwy, Annapolis, MD - Aerial map view
Moderately walkable
60/100
Exceptionally drivable
100/100
Limited public transit
30/100
Somewhat bikeable
30/100
Source: Local Logic®
(410) 685-9885

Still interested?

Contact the brokers for more information about this property

Contacts

  • Laura Westervelt
    Laura Westervelt
  • Ryan J. Brant
    Ryan J. Brant
  • Ryan Brassel
    Ryan Brassel

  • Listing ID: 41176505

  • Date on Market: 7/6/2026

  • Last Updated:

  • Address: 116 Defense Hwy, Annapolis, MD 21401

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116 Defense Hwy
(410) 685-9885 x

116 Defense Hwy

Laura Westervelt
(410) 685-9885

Ryan J. Brant
(301) 768-2710

Ryan Brassel
(410) 507-3144

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